Anti-Aging

MOTS-c

Mitochondrial-derived peptide studied for metabolic regulation and exercise-mimetic effects.

Research use only · U.S. cGMP-aligned sourcing

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Research overview

MOTS-c is a naturally occurring peptide, notable for being encoded by the mitochondrial genome rather than the nuclear genome, which is the source of nearly all other proteins. It is classified as a mitochondrially-derived peptide, originating from a small open reading frame within the 12S ribosomal RNA gene.

It functions as a systemic metabolic regulator and is considered an "exerkine" — a signaling molecule released into circulation in response to exercise that helps mediate the beneficial effects of physical activity. The primary proposed mechanism of action for MOTS-c involves the activation of the AMP-activated protein kinase (AMPK) pathway. As AMPK is a master sensor of cellular energy status, its activation by MOTS-c helps promote glucose uptake, enhance fatty acid oxidation, and improve overall insulin sensitivity.

By mimicking some of the fundamental metabolic benefits of exercise, MOTS-c is being investigated in preclinical studies as a potential therapeutic agent for a range of age-related and metabolic conditions, including type 2 diabetes, obesity, and sarcopenia (age-related muscle loss).

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

1.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, et al. — Cell Metabolism, 2015
2.
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
Kim SJ, et al. — Free Radical Biology and Medicine, 2018
3.
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
Cobb LJ, et al. — Aging, 2016

Studied benefits

Mitochondrial-encoded regulatory peptide
Improves insulin sensitivity in studies
Investigated as exercise mimetic
Activates AMPK pathway

Research notice: Research use only. Typical study ranges: 5–10 mg, 2–3x weekly. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.

U.S. Sourcing Network

Trusted U.S. research-peptide suppliers

We source and benchmark against established U.S.-based research-peptide manufacturers and distributors. Each supplier below operates under cGMP-aligned synthesis with documented CoA, HPLC, and mass-spec validation for research use only.

Bachem

AnaSpec

GenScript

Thermo Fisher Scientific

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