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Growth Hormone

Ipamorelin

Selective ghrelin mimetic with minimal impact on cortisol or prolactin.

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Ipamorelin
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Research overview

Ipamorelin is a synthetic pentapeptide and a selective agonist of the Growth Hormone Secretagogue Receptor (GHSR-1a), the same receptor activated by the endogenous hormone ghrelin. It belongs to the Growth Hormone-Releasing Peptide (GHRP) class of growth hormone secretagogues.

Its mechanism of action involves binding to GHSR-1a in the anterior pituitary gland and hypothalamus, triggering a pulsatile release of the body's own growth hormone (GH). Ipamorelin is distinguished within its class by its high degree of selectivity: unlike earlier GHRPs such as GHRP-2 and Hexarelin, it stimulates GH release with minimal impact on other hormones, producing little to no elevation in cortisol, prolactin, or aldosterone, and without significantly increasing appetite.

This clean pharmacological profile has made Ipamorelin a widely studied experimental peptide. It is often investigated in combination with a Growth Hormone-Releasing Hormone (GHRH) analogue such as CJC-1295, where the two compounds act on complementary pathways to produce a synergistic increase in GH and Insulin-like Growth Factor 1 (IGF-1) levels.

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

  1. 1.
    Ipamorelin, the first selective growth hormone secretagogue
    Raun K, et al. — European Journal of Endocrinology, 1998
  2. 2.
  3. 3.

Studied benefits

  • Stimulates pulsatile GH release
  • Supports lean mass preservation
  • Improves recovery and sleep
  • Minimal side-effect profile in studies
Research notice: Research use only. Typical study ranges: 200–300 mcg, 1–3x daily. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.
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Related peptides

Growth Hormone
CJC-1295 with DAC

Long-acting GHRH analog with Drug Affinity Complex, designed to sustain elevated GH and IGF-1 levels.

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CJC-1295 (No DAC) / Mod GRF 1-29

Short-acting GHRH analog (Mod GRF 1-29) studied for pulsatile GH release with rapid clearance.

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GHRP-2

Growth Hormone Releasing Peptide-2 studied for potent, pulsatile GH release.