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Growth Hormone

CJC-1295 (No DAC) / Mod GRF 1-29

Short-acting GHRH analog (Mod GRF 1-29) studied for pulsatile GH release with rapid clearance.

Research use only · U.S. cGMP-aligned sourcing
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CJC-1295 (No DAC) / Mod GRF 1-29
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Research overview

CJC-1295 without DAC (Drug Affinity Complex) is a synthetic peptide analogue of Growth Hormone-Releasing Hormone (GHRH). It is also commonly referred to as Modified GRF (1-29) or Mod GRF 1-29.

Its mechanism of action involves binding to GHRH receptors in the anterior pituitary gland. This stimulation signals the pituitary to release the body's own supply of growth hormone (GH). The defining characteristic of this peptide is its short biological half-life, which is typically under 30 minutes. This is because it lacks the DAC modification that otherwise extends its duration of action.

The result is a pulsatile release of GH that closely mimics the natural secretion patterns of the human body. It is investigated for its effects on serum GH and Insulin-like Growth Factor 1 (IGF-1) levels and is often studied in combination with a Growth Hormone-Releasing Peptide (GHRP) to produce a synergistic effect.

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

  1. 1.
    Modified GRF(1-29) and growth hormone secretagogues: clinical applications
    Sinha DK, et al. — Translational Andrology and Urology, 2020
  2. 2.
    Growth hormone-releasing hormone (GHRH) and its analogues
    Frohman LA, Kineman RD. — Endocrine Reviews, 2002
  3. 3.
    Most cited Mod-GRF / GHRH(1-29) studies (PubMed)
    Multiple authors — PubMed search

Studied benefits

  • Stimulates short, natural GH pulses
  • Rapid onset and clearance
  • Frequently paired with Ipamorelin
  • Minimal impact on baseline GH biology
Research notice: Research use only. Typical study ranges: 100 mcg, 1–3x daily. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.
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