CJC-1295 with DAC
Long-acting GHRH analog with Drug Affinity Complex, designed to sustain elevated GH and IGF-1 levels.
Research overview
CJC-1295 with DAC is a long-acting synthetic analogue of Growth Hormone-Releasing Hormone (GHRH). Like other GHRH analogues, it stimulates the anterior pituitary gland to release endogenous growth hormone.
The key feature of this molecule is the inclusion of a "Drug Affinity Complex" (DAC). This technology allows the peptide to bind to albumin, a protein circulating in the blood plasma, which protects it from rapid enzymatic degradation and clearance. This binding significantly extends its biological half-life to approximately one week.
In contrast to the short, pulsatile release of growth hormone (GH) induced by its "no DAC" counterpart, CJC-1295 with DAC produces a continuous and sustained elevation of both GH and Insulin-like Growth Factor 1 (IGF-1) levels. This prolonged, non-pulsatile effect is sometimes referred to as a "GH bleed." It is investigated for its potential applications where a sustained increase in growth hormone levels is desired.
Peer-Reviewed Research (PubMed)
Selected landmark / highly-cited studies indexed on PubMed.
- 1.
- 2.A single dose of the GH-releasing hormone analogue CJC-1295 causes a 7-10 day increase in GH and IGF-I in healthy adultsIonescu M, Frohman LA. — JCEM, 2006
- 3.Most cited CJC-1295 studies (PubMed)Multiple authors — PubMed search
Studied benefits
- Sustains elevated GH and IGF-1 levels
- Enhances recovery and protein synthesis
- Promotes deeper sleep cycles
- Pairs synergistically with ghrelin mimetics
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