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Weight Management

HGH Fragment 176-191

C-terminal hGH fragment studied for fat-loss effects without growth or insulin-axis impact.

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HGH Fragment 176-191
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Research overview

HGH Fragment 176-191 is a synthetic peptide that represents a specific segment of the full human growth hormone (HGH) molecule. It consists of the 16 amino acids located at the C-terminal end of the HGH chain, from positions 176 to 191.

The development of this fragment is based on the scientific hypothesis that the fat-regulating effects of HGH are primarily localized to this region of the hormone. The objective was to isolate the lipolytic (fat-burning) properties of HGH while excluding other systemic effects, such as the stimulation of Insulin-like Growth Factor 1 (IGF-1), effects on growth, or significant alterations in insulin sensitivity.

Its proposed mechanism of action involves the direct stimulation of lipolysis (the breakdown of fat) and the inhibition of lipogenesis (the formation of new fat), specifically targeting adipose tissue. Unlike the full HGH molecule, it is not intended to influence cell proliferation or growth. It is an experimental peptide investigated for its potential effects on fat metabolism and is the parent compound from which more stabilized analogues, such as AOD9604, were derived.

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

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    The lipolytic and antilipogenic activity of growth hormone fragments 176-191
    Ng FM, et al. — Hormone and Metabolic Research, 1990

Studied benefits

  • Targets adipose tissue lipolysis
  • Inhibits lipogenesis
  • Does not affect blood glucose
  • No IGF-1 elevation in studies
Research notice: Research use only. Typical study ranges: 250–500 mcg/day. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.
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