Weight Management

Cagrilintide

Long-acting amylin analog investigated for appetite regulation and weight management, often paired with GLP-1 agonists.

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Research overview

Cagrilintide is an investigational, long-acting amylin analogue. Amylin is a hormone naturally produced in the pancreas and co-secreted with insulin following a meal. It plays a role in glucose regulation and appetite control.

The mechanism of action for Cagrilintide involves mimicking native amylin. It acts on receptors in the brain to induce satiety (a feeling of fullness) and slows the rate of gastric emptying. These actions are understood to contribute to a reduction in overall caloric intake.

Cagrilintide is being clinically evaluated for its application in weight management. Research is assessing its effects both as a standalone therapy and in a fixed-dose combination with a GLP-1 receptor agonist, semaglutide (this combination is known as CagriSema).

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

1.
Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled, dose-finding phase 2 trial
Lau DCW, et al. — The Lancet, 2021
2.
Semaglutide 2.4 mg once weekly in combination with cagrilintide 2.4 mg once weekly (CagriSema) in adults with overweight or obesity
Enebo LB, et al. — The Lancet, 2021
3.
Discovery of the long-acting amylin analogue cagrilintide
Kruse T, et al. — Journal of Medicinal Chemistry, 2021

Studied benefits

Activates amylin and calcitonin receptors
Suppresses appetite and slows gastric emptying
Synergistic effect with semaglutide (CagriSema)
Once-weekly administration profile

Research notice: Research use only. Titrated weekly dosing per study protocol. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.

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