AOD-9604
Modified hGH fragment (176–191) studied for fat metabolism without affecting glucose or IGF-1.
Research overview
AOD-9604 is a synthetic peptide analogue derived from the C-terminal region of human growth hormone (hGH), encompassing the amino acid sequence 176-191. Its molecular structure is modified by the inclusion of a disulfide bridge, a covalent bond that confers increased stability. This alteration renders the peptide more resistant to enzymatic degradation, potentially prolonging its biological activity.
Initially investigated for its lipolytic (fat-burning) properties, AOD-9604 has demonstrated a dual-action mechanism in preclinical animal models. It stimulates lipolysis, the process involving the breakdown and release of stored triglycerides from adipocytes. Concurrently, it inhibits lipogenesis, the metabolic pathway responsible for the synthesis and accumulation of new fat.
In addition to its primary metabolic function, subsequent research has indicated therapeutic potential in other areas. Studies suggest AOD-9604 may promote the regeneration of damaged cartilage in osteoarthritis, and its potential applications are being explored in relation to cardiovascular health and the management of metabolic syndrome.
Peer-Reviewed Research (PubMed)
Selected landmark / highly-cited studies indexed on PubMed.
- 1.The lipolytic effects of AOD9604, a synthetic analogue of the lipolytic domain of human growth hormoneHeffernan M, et al. — Endocrinology, 2001
- 2.AOD9604, a human growth hormone fragment, in obesity: a randomized, double-blind, placebo-controlled trialStier H, et al. — Trials in Obesity, 2013
- 3.Mechanism of action of an antiobesity peptide (AOD9604) on adipocyte metabolismNg FM, et al. — Hormone Research, 2000
Studied benefits
- Stimulates lipolysis in adipose tissue
- Inhibits lipogenesis
- No effect on blood glucose or IGF-1
- Investigated for cartilage repair
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