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Hormonal

Kisspeptin-10

Decapeptide regulator of GnRH neurons, studied for reproductive axis activation.

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Kisspeptin-10
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Research overview

Kisspeptin-10 is a synthetic decapeptide, composed of ten amino acids. It represents the C-terminal sequence and the minimal, fully active fragment of the larger, naturally occurring kisspeptin peptides (such as Kisspeptin-54) that are encoded by the KISS1 gene.

As the core functional unit, its mechanism of action is to serve as a potent agonist for the kisspeptin receptor, KISS1R. By binding to these receptors on hypothalamic neurons, Kisspeptin-10 powerfully stimulates the release of Gonadotropin-Releasing Hormone (GnRH). This stimulation of GnRH, in turn, drives the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), making Kisspeptin-10 a direct and primary driver of the Hypothalamic-Pituitary-Gonadal (HPG) axis.

Due to its well-defined structure and potent activity, Kisspeptin-10 is frequently used in clinical and preclinical research as a tool to directly probe the function of the HPG axis and investigate disorders related to puberty and fertility.

Peer-Reviewed Research (PubMed)

Selected landmark / highly-cited studies indexed on PubMed.

  1. 1.
  2. 2.
    Kisspeptin: a novel regulator of reproductive function
    Roa J, et al. — Reviews in Endocrine and Metabolic Disorders, 2008
  3. 3.
    The GPR54 gene as a regulator of puberty
    Seminara SB, et al. — NEJM, 2003

Studied benefits

  • Master regulator of GnRH neurons
  • Stimulates LH and FSH release
  • Studied in fertility research
  • Upstream of HPG axis
Research notice: Research use only. Typical study ranges: 1–10 mcg/kg. All information is provided strictly for laboratory and educational reference. Not for human consumption. This compound is not approved by the FDA for human or veterinary therapy.
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